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Items 13 - 23 Daily subcutaneous parecoxib injection for cancer pain: an open label However, dating of subcutaneous hematomas based on their external. Efficacy and safety of Postoperative Intravenous Parecoxib sodium Followed by ORal CElecoxib (PIPFORCE) post-total knee arthroplasty in patients with. (VIOXX) were apparent in the body of studies dating back to , parecoxib (DYNASTAT) is still available in Europe, and other drugs in.

Javascript is currently disabled Parecoxib fdating your browser. Several features of this site will not function whilst javascript is disabled. Received 28 September Published 19 April Parecoxib fdating Peer reviewers approved by Parecoxib fdating Colin Mak. Editor who Parecoxib fdating publication: Dr Michael E Schatman.

The Parecoxib fdating aimed to assess the combined effects of parecoxib with three different doses of remifentanil and its effect on the stress and cough responses following tracheal extubation under general Parecoxib fdating. A total of patients with American Society Parecoxib fdating Anesthesiologists ASA scores of I or II, undergoing selective thyroidectomy with total intravenous anesthesia propofol-remifentanil and tracheal intubation, were randomly allocated to be treated with an intravenous injection of parecoxib and a continuous infusion of remifentanil at 0.

Hemodynamic vital signs, emergence time, extubation time, sedation-agitation Parecoxib fdating SAS score, pain visual analog scale VAS Parecoxib fdating, occurrence of coughing, and side effects were recorded before surgery and during the peri-extubation period. The combined use of parecoxib and a moderate dose of remifentanil can effectively suppress the stress and coughing responses during the peri-extubation period.

The appropriate quantity of remifentanil was found to be 0. Tracheal extubation is commonly performed Parecoxib fdating the emergence phase after stopping anesthetics. Significant systemic stress responses to pain and airway stimulation can occur during this period, including agitation and cough, which may cause hypertension, tachycardia, and increased intracranial hypertension.

Traditionally, anesthetic withdrawal involves discontinuing both propofol and remifentanil, which can result Parecoxib fdating pain experienced by patients in an unawakened state and which can lead Parecoxib fdating a stress response induced by the tracheal catheter. This widely increases the probability of dysphoria Parecoxib fdating adverse reactions during the peri-extubation period. Therefore, it is extremely important to identify a method to effectively reduce the stress response during peri-extubation.

Therefore, remifentanil is widely used for clinical anesthesia. The use of a continuous infusion of remifentanil after total intravenous anesthesia has multiple advantages, as remifentanil can be used to control excessive stress responses. As a previous study showed, the use of remifentanil often results in postoperative discomfort and hyperalgesia.

Parecoxib fdating is a new nonsteroidal anti-inflammatory drug NSAID that has selective cyclooxygenase-2 inhibitory activity, strong anti-inflammatory analgesic activity, long-term efficacy, 8 and minimal cardiovascular risk. Until now, the appropriate dose of remifentanil for inhibiting Parecoxib fdating responses has remained unclear. The stress response that occurs Parecoxib fdating major surgeries is not only related to the irritation caused by the endotracheal tube but also to the surgical stimulation of patients Parecoxib fdating the emergence phase.

Therefore, this study aimed to Parecoxib fdating the combined effect of parecoxib with different doses of Parecoxib fdating on hemodynamic vital signs and stress responses to extubation.

Patients with the following characteristics were excluded from the study: The included patients were Parecoxib fdating divided into four groups with 30 patients per group: After entering the operating room, the blood pressure BPheart rate HRrespiratory rate Rand peripheral arterial oxygen saturation SPO 2 of each patient Parecoxib fdating routinely monitored.

After the patient reached a stable condition, anesthesia induction was performed. When suturing the incision, the patients Parecoxib fdating all four groups received an intravenous infusion of parecoxib 40 mg and an intravenous drip of tropisetron 4 mg. The patients in the control group received an isotonic saline injection instead of propofol and remifentanil.

In contrast, the Parecoxib fdating in groups R1, R2, and R3 were treated with intravenous Parecoxib fdating at 0. Patients Parecoxib fdating could open their eyes on command and responded to commands were assessed as being conscious. Extubation and discontinuation of remifentanil were Parecoxib fdating when the patients had Parecoxib fdating following conditions: The emergence time was defined as the time between discontinuation of propofol and the point at which the patient regained consciousness.

The extubation time was defined as time between the discontinuation of propofol and extubation. The operation, emergence, and extubation times of each patient were recorded.

The times and severity of cough during the extubation time were recorded. Anesthesia- extubation- and remifentanil-related adverse reactions were also Parecoxib fdating, which included intraoperative awareness, comfort level during extubation, cough, laryngospasm, encephalalgia, dizziness, nausea, emesis, uroschesis, and skin pruritus.

Statistical analyses were performed using SPSS A normality test was carried out for each Parecoxib fdating variable. The non-normally distributed data are presented as medians with rangesand comparison among the groups was performed using nonparametric tests.

As shown, gender, age, surgical time, nausea, emesis, dizziness, headache, intraoperative awareness, and uroschesis in the control, R1, R2, and R3 groups were not significantly different Table 1. The emergence and extubation times were different among the groups, with increases in remifentanil dose, and considerably longer times in group R2 Parecoxib fdating at 0.

Parecoxib fdating small number of patients in the Parecoxib fdating and low-dose remifentanil groups were aware but did not experience discomfort These results indicated that continuous postoperative infusion of remifentanil can not only reduce coughing and discomfort responses Parecoxib fdating extubation but they can also increase respiratory depression and bradycardia.

Table 1 Comparison of patient characteristics and postoperative complications. BMI, body mass index; C, sodium chloride; R1, remifentanil 0.

These data were analyzed using GEEs, and the results are shown in Tables 2 — 5respectively. C, sodium chloride; R1, remifentanil Parecoxib fdating. Table 3 Correlation between SAS and the dose and infusion time Parecoxib fdating remifentanil. Table 5 Correlation between VAS and the dose and infusion time of remifentanil. The SPO 2 of the remifentanil groups showed no significant change Table 6. These results suggest that postoperative remifentanil infusions can decrease the rise in systolic and diastolic BP, HR, and R at emergence and extubation, and they showed that the effect of a high dose of remifentanil on these variables was longer and better.

Many studies have been carried out to explore Parecoxib fdating methods that can effectively alleviate stress responses, agitation, and discomfort due to tracheal extubation during the Parecoxib fdating time from general anesthesia.

Vasoactive drugs, such as esmolol and ebrantil, can be used to inhibit cardiovascular responses to tracheal extubation. However, they can only improve tachycardia and hyperpiesia, and fail to inhibit the intense stimulation of the trachea by the tracheal catheter and to effectively stop the agitation and discomfort during Parecoxib fdating peri-extubation period.

However, the controllability of long-acting opioid analgesics is poor due to longer elimination half-life and prolonged context-sensitive half-life. The use of fentanyl can not only reduce stress responses but it can also induce respiratory depression and delay recovery. Remifentanil is a new kind of ultra-short-acting opioid analgesic. It has many advantages such as rapid onset, shorter elimination half-life, no accumulation after long-term application, no effect caused by impaired hepatorenal function, and no prolonged context-sensitive half-life.

Furthermore, the patients treated with remifentanil had no significant adverse effects Parecoxib fdating as nausea, emesis, dizziness, headache, or uroschesis. The occurrence rates Parecoxib fdating cough and discomfort were effectively reduced, and there was Parecoxib fdating obvious occurrence of respiratory depression or bradycardia among the Parecoxib fdating treated with remifentanil at 0.

The fact that continuous injection of remifentanil after surgery can inhibit airway reflex and attenuate the stimulus of tracheal tube may account for the Parecoxib fdating. Previous research has suggested that Parecoxib fdating does not cause a decrease in the bispectral index value, 17 which may be inversely correlated with the level of analgesia.

This demonstrates that Parecoxib fdating postoperative use of a low dose of remifentanil can ameliorate any changes Parecoxib fdating BP and HR during the peri-extubation period, and it has beneficial effects on hemodynamic stability.

Furthermore, use of remifentanil at 0. Therefore, continuous postoperative infusion of remifentanil at a dose of 0.

JS substantially contributed to the conception and design of this study; GZ, XY, and YL substantially contributed to the acquisition of data, or analysis and interpretation of data; GZ and XY wrote the manuscript; JS revised it critically for important intellectual content and agreed to be accountable for all aspects of the work in ensuring that Parecoxib fdating related to the accuracy or integrity of any part of Parecoxib fdating work are appropriately investigated and resolved.

All authors contributed toward data analysis, drafting and revising the paper and agree to be accountable for all aspects of the work. Cardiovascular and plasma catecholamine responses at tracheal extubation. Assessment of peri-extubation pain by visual analogue scale in the adult intensive care unit: A review of the pharmacokinetics and pharmacodynamics of remifentanil. Japanese [with English abstract]. Parecoxib fdating low-dose remifentanil infusion is well tolerated for sedation in mechanically Parecoxib fdating, critically-ill patients.

Neuroendocrine stress response in gynecological laparoscopy: TIVA with propofol versus sevoflurane anesthesia. The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia. A randomized, double-blinded study of remifentanil versus fentanyl for tonsillectomy and adenoidectomy surgery in pediatric ambulatory surgical patients.

Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine Parecoxib fdating effects: Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients.

Kovac AL, Masiongale A. Comparison of nicardipine versus esmolol in attenuating the hemodynamic responses to anesthesia emergence and extubation. Parecoxib fdating Cardiothorac Vasc Anesth.

Safavi M, Honarmand A. Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation — intravenous sufentanil vs pethidine. Middle East J Anaesthesiol. Beers R, Camporesi E. Reduced incidence of laryngospasm with remifentanil-midazolam anaesthesia compared to halothane-fentanyl. J Pak Med Assoc. The effect of remifentanil on the bispectral index change and hemodynamic responses after orotracheal intubation.

The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. A comparison of two constant-dose continuous infusions of remifentanil for severe postoperative pain. Remifentanil Parecoxib fdating tracheal Parecoxib fdating tolerance: Lippincott, Williams and Wilkins; Small doses of remifentanil or sufentanil for blunting Parecoxib fdating changes induced by tracheal intubation: This work is Parecoxib fdating and licensed by Dove Medical Press Limited.

The full terms of this license are available at https: By accessing the work you hereby accept the Parecoxib fdating.

Whats'up with all that Ex talk? Daily subcutaneous parecoxib injection for cancer pain: an open label pilot However, dating of subcutaneous hematomas based on their. Paramethasone, The metabolism of Paramethasone can be increased when combined with Metamizole. Parecoxib, The risk or severity of adverse effects can be..

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Received 30 April Published 25 November Volume Look reviewers approved by Dr Kerui Gong. Editor who approved publication: Dr Michael E Schatman. To inquire the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. The current study adds weather for the use of parecoxib in patients following major gynecologic surgery.

That work is published and licensed by Dove Medical Press Limited. The wholly terms of this sanction are available at https:

Anecdote issue that remained uncertain was whether, as a class, all COX-2 inhibitor drugs had similar adverse effects, especially on jeopardy of kidney and soul rhythm disorders. Notably, the study found that barely VIOXX was associated with increased renal and arrhythmia risks; the other drugs in the class did not show increased risks. Renal effects have to do with the kidney, blood pressure, and formless retention; arrhythmia is an irregularity in the intimidate or rhythm of the heartbeat.

The articles command appear in print in the Oct. Another essential finding in this meta-analysis is that the adverse renal effects of rofecoxib VIOXX were apparent in the body of studies dating back to Inflexibility, if careful safety monitoring of the data had been carried out. Exacting COX-2 inhibitors were developed by pharmaceutical companies as drugs for relieving grief without the adverse gastrointestinal side effects of old non-steroidal anti-inflammatory drugs NSAIDs , estimated to be used daily by more than 30 million folk worldwide.

However, the adverse renal and arrhythmia risks have been relatively unbeknownst for all COX-2 inhibitors. In one of the largest systematic reviews for ever conducted in the medical literature, the investigators examined more than trial reports and aggregated data from double-blinded, randomized trials comprised of more than participants, in order to examine the effects of the entire class of COX-2 inhibitors drugs: The large sample size allowed the researchers to study the effects of mortal drugs within the loose class of COX-2 inhibitors.

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